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Syphilis can be cured with antibiotics, but many people don't notice the early symptoms. It can lead to nerve damage, blindness, paralysis, and even death over time if not treated. The first sign is typically a painless sore on the genitals or anal area. It is usually round and firm. A rash can develop later on the soles of the feet, palms, or other parts of the body. Other symptoms can include enlarged lymph nodes, fever, fatigue, or hair loss. Late-stage syphilis can cause damage to many different organ systems.


Syphilis (other than congenital syphilis) occurs in four stages that sometimes overlap.

Primary Syphilis:

The first symptom of primary syphilis is often a small, round, firm ulcer (sore) called a chancre ("shanker") at the place where the bacteria entered your body. This place is usually the penis, vulva, or vagina, but chancres also can develop on the cervix, tongue, lips, or other parts of the body. Usually there is only one chancre, but sometimes there may be many. Nearby lymph glands are often swollen. (Lymph glands, or nodes, are small bean-shaped organs of your immune system containing cells that help fight off germs. They are found throughout your body.) The chancre usually appears about 3 weeks after you're infected with the bacteria, but it can occur any time from 9 to 90 days after you have been infected.

Because a chancre is usually painless and can appear inside your body, you might not notice it. The chancre disappears in about 3 to 6 weeks whether or not you are treated. Therefore, you can have primary syphilis without symptoms or with only brief symptoms that you may overlook. If primary syphilis is not treated, however, the infection moves to the secondary stage.


Secondary syphilis:

Most people with secondary syphilis have a skin rash that doesn't itch. The rash is usually on the palms of your hands and soles of your feet. However, it may cover your whole body or appear only in a few areas. The rash appears 2 to 10 weeks after the chancre, generally when the chancre is healing or already healed. Other common symptoms include:

Sore throat



Swollen lymph glands

Other symptoms that happen less often include fever, aches, weight loss, hair loss, aching joints, or lesions (sores) in the mouth or genital area.

Your symptoms may be mild. The lesions of secondary syphilis contain many bacteria, and anyone who has contact with them can get syphilis. As with primary syphilis, secondary syphilis will seem to disappear even without treatment, but secondary syphilis can return. Without treatment, however, the infection will move to the next stages.


Latent syphilis:

The latent (hidden) stage of syphilis begins when symptoms of secondary syphilis are over.In early latent syphilis, you might notice that signs and symptoms disappear, but the infection remains in your body. When you are in this stage, you can still infect a sexual partner.In late part of latent syphilis, the infection is quiet and the risk of infecting a sexual partner is low or not present. If you don't get treated for latent syphilis, you may move on to tertiary syphilis, the most serious stage of the disease.


Tertiary syphilis:

Even without treatment, only a small number of infected people develop the dreaded complications known as tertiary, or late, syphilis. In this stage, the bacteria will damage your heart, eyes, brain, nervous system, bones, joints, or almost any other part of your body. This damage can happen years or even decades after the primary stage.Late syphilis can result in mental illness, blindness, deafness, memory loss or other neurologic problems, heart disease, and death. Late neurosyphilis (brain or spinal cord damage) is one of the most severe signs of this stage.



Syphilis is caused by a bacterium called Treponema pallidum.



The most common way to get syphilis is by having sexual contact with an infected person. If you are infected, you can pass the bacteria from infected skin or mucous membranes (linings), usually your genital area, lips, mouth, or anus, to the mucous membranes or skin of your sexual partner.The bacteria are fragile, so you cannot get syphilis from sharing food or utensils, or from using tubs, pools, or toilets.Syphilis can be passed from mother to infant during pregnancy, causing a disease called congenital syphilis.



Syphilis is sometimes called "the great imitator." This is because it has so many possible symptoms, and its symptoms are like those of many other diseases. Having HIV infection at the same time as syphilis can change the symptoms of syphilis and how the disease develops. 


It can be very difficult for your healthcare provider to diagnose syphilis based on symptoms. This is because symptoms and signs of the disease might be absent, go away without treatment, or be confused with those of other diseases. Because syphilis can be hard to diagnose, you should

Visit your healthcare provider if you have a lesion (sore) in your genital area or a widespread rash

Get tested periodically for syphilis if your sexual behaviors put you at risk for sexually transmitted diseases (STDs)

Get tested to be sure you don't also have syphilis if you have been treated for another STD such as gonorrhea or HIV infection


Laboratory Tests:

Your healthcare provider can diagnose early syphilis by seeing a chancre or rash and then confirming the diagnosis with laboratory tests. Because latent syphilis has no symptoms, it is diagnosed only by laboratory tests.


There are two methods for diagnosing syphilis through a laboratory.

►Identifying the bacteria under a microscope in a sample of tissue (a group of cells) taken from a chancre.

►Performing a blood test for syphilis

If your healthcare provider thinks you might have neurosyphilis, your spinal fluid will be tested as well.



Syphilis is easy to cure in its early stages.An antibiotic, injected into the muscle, is the best treatment for syphilis. If you are allergic to one antibiotic, your healthcare provider may give you another antibiotic to take by mouth.

►If you have neurosyphilis, you may need to get daily doses medicine prescribed by doctor and you may need to be treated in the hospital.

►If you have late syphilis, damage done to your body organs cannot be reversed.

While you are being treated, you should abstain from sex until any sores are completely healed. You should also notify your sex partners so they can be tested for syphilis and treated if necessary.